Paquette Lab
Seattle Children's Research Institute
Center for Developmental Biology and Regenerative Medicine
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Fetal development is a short period of time that affects health throughout the lifespan. The placenta is a crucial organ that regulates the in-utero environment and alters development. Our lab applies a precision medicine framework to understand the link between environmental exposures, maternal nutrition, and other factors and infant health outcomes. We develop and share computational tools for multi-omics data integration using placental networks.
Our long-term goal is to gain insight into the underlying molecular mechanisms linking the in-utero environment to infant and child health outcomes by applying innovative network biology approaches and multi-omic data analyses within the placenta.
Our long-term goal is to gain insight into the underlying molecular mechanisms linking the in-utero environment to infant and child health outcomes by applying innovative network biology approaches and multi-omic data analyses within the placenta.
Tackling Spontaneous Preterm Birth through a Precision Environmental Health Lens
We are currently applying this approach to identify risk factors for spontaneous preterm birth. Preterm birth is the leading cause of infant morbidity and mortality, and preterm infants require intensive acute and long-term care. More research is needed to understand the underlying risk factors and mechanisms leading to spontaneous preterm birth. We are investigating links between prenatal factors (nutrition, environmental exposures) and spontaneous preterm birth using multi-omics data.
SUPPORT
Our lab is supported by the NICHD (R00HD09611, PI Paquette), NIEHS (R01ES033785 - Outstanding New Environmental Scientist award, PI Paquette), the Brotman Baty Institute (Catalytic Collaboration Grant) and Seattle Children's Research Institute.
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