Publications

Dr. Paquette's NCBI Bibliography

Featured Publications

Mono-ethylhexyl phthalate induces overall and sex-specific transcriptomic changes in placental cells

Lapehn S, Scott Houghtaling S, Ahuna K, Kadam L, MacDonald J, Bammler T, LeWinn K, Karr C, Myatt L, Sathyanarayana S, Paquette AG. Archives of Toxicology, Published 1/25/2023.

Main Findings

The phthalate metabolite MEHP differentially affects placental gene expression based on concentration, fetal sex, and trophoblast cell type
Four Ligand-inducible TFs (PPARG, PPARD, ESR1, AR) were enriched as regulators of genes whose expression was altered after MEHP treatment
A higher number of transcriptomic changes were noted in male primary placental cells, which is concurrent with our work in banked placental tissue samples.

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Paquette AG, Lapehn S, Freije S, MacDonald J, Bammler T, Day D, Loftus C, Kurunthachalam K, W. Alex Mason, PhD; Nicole R. Bush, PhD; Kaja Z LeWinn, ScD; Daniel A. Enquobahrie, MD, PhD, MPH; Carmen Marsit PhD; Catherine J Karr, MD, PhD, MS; Sheela Sathyanarayana, MD, MPH. s. Environment International. Published 1/18/2023.

Main Findings

We identified changes to the placental transcriptome associated with 6 PH Metabolites including multiple associations with TRIP13 and SGF29
Increased expression of genes within pathways involving vitamin digestion and absorption, insulin secretion, and the lysosome-related to 4 OH-PAH metabolites
Evidence that Sex may modify relationships between OH-PAH metabolites and placental gene expression

All Publications

Note: Publications here are only include articles published after 2020 and may not be updated. Please check my google scholar page or my NCBI bibliography for updates.

Preprints

Baker B, Sathyanarayana S, Szpiro A, MacDonald J, Paquette AG. RNAseqCovarImpute: a multiple imputation procedure that outperforms complete case and single imputation differential expression analysis. BioRxiv. doi:doi.org/10.1101/2023.05.11.540260

Paquette AG, Ahuna K, Hwang Y, Pearl J, Liao H, Shannon P, Kadam L, Lapehn S, Bucher M, Roper R, Funk C, MacDonald J, Bamler T, Baloni P, Brockway H, Mason A, Bush N, LeWinn K, Karr C, Stamatoyannopoulos J, Muglia L, Jones H, Sadovsky Y, Myatt L, Sathyanarayana S, Price N. A Genome Scale Transcriptional Regulatory Model of the Human Placenta. BioRxiv. Published online September 28, 2022. doi: https://doi.org/10.1101/2022.09.27.509541

2023

Elkin A, Campbell KA, Lapehn S, Harris SM, Padmanabhan V, Bakulksi K, Paquette AG. Placental Single Cell Transcriptomics: Opportunities for Endocrine Disrupting Chemical Toxicology. Molecular and Cellular Endocrinology. Published September 9, 2023. doi: doi.org/10.1016/j.mce.2023.112066

Hussey M, Enquobahrie D, Loftus CR, MacDonald JR, Bammler TK, Paquette AG, , Marsit C, Szpiro A, Kaufman J, LeWinn KZ, , Tylavsk F, Bush NR, Zhao Q, Karr C, Sathyanarayana S. Associations of prenatal exposure to NO2 and near roadway residence with placental gene expression. Placenta, Published July 2023. doi:doi.org/10.1016/j.placenta.2023.05.004

Laphen S, Gustafson J, Timms A, Cunningham M, Paquette AG. Transcriptomic signatures of single-suture craniosynostosis. International Journal of Molecular Sciences. Published March 10, 2023. doi: doi.org/10.3390/ijms24065353

Correia-Branco A, Mei A, Pillai S, Jayaraman N, Sharma R, Paquette AG, Neradugomma NK, Benson C, Chavkin N, Mao Q, Wallingford MC. SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis. Vascular Biology. Published April 19, 2023. DOI: doi.org/10.1530/VB-22-0018

Lapehn S, Scott Houghtaling S, Ahuna K, Kadam L, MacDonald J, Bammler T, LeWinn K, Karr C, Myatt L, Sathyanarayana S, Paquette AG. Mono-ethylhexyl phthalate induces overall and sex-specific transcriptomic changes in placental cells. Archives of Toxicology, Published 1/25/2023. doi: doi.org/10.1007/s00204-023-03444-0

2022

Kruger L, Yue G, Paquette AG, Sathyanarayana S, Enquobahrie DA, Bammler T, MacDonald J, Zhao Q, Prasad B. An optimized proteomics-based approach to estimate blood contamination and cellular heterogeneity of frozen placental tissue. Placenta. Published 12/23/2022. doi https://doi.org/10.1016/j.placenta.2022.12.007

LeWinn K, Karr C, Hazelhurst M, Carroll K, Loftus C, Nguyen R, Barrett E, Swan S, Spziro A, Paquette AG, Moore P, Spalt E, Younglove L, Sullivan A, Colburn T, Byington N, Sims Taylor L, Moe S, Wang S, Cordeiro A, Mattias A, Powell J, Johnson T, Norona-Zhou A, Mason A, Bush N, Sathyanarayana S. Cohort Profile: The Prenatal and Early Childhood Pathways to Health (PATHWAYS) Consortium. BMJ Open, Published 10/1/2022. doi: http://dx.doi.org/10.1136/bmjopen-2022-064288

Paquette AG, MacDonald J, Bammler T, Day DB, Loftus C, Buth E, Mason WA, Bush NR, LeWinn KZ, Marsit CJ, Litch J, Gravett, M, Enquobahrie DA, Sathyanarayana S. Transcriptomic Signatures of Spontaneous Preterm Birth. American Journal of Obstetrics and Gynecology. Published online July 19, 2022.doi: doi.org/10.1016/j.ajog.2022.07.015

Hsieh L*, Tu L*, Paquette AG*, Sheng Q, Zhao S, Bittel D, O'Brien J, Vickers K, Pastuzsko P, Nigam V. microRNA Expression Levels Change in Neonatal Patients During and After Exposure to Cardiopulmonary Bypass. Journal Of the American Heart Association, Published 9/6/2022. doi: https://doi.org/10.1161/JAHA.122.025864

Jamet S, Ha S, Ho O, Houghtaling S, Timms A ,Yu K, Paquette AG, Maga M, Greene N, Beier DR. The Arginine Methyltransferase Carm1 is Necessary for Heart Development. G3: Genes | Genomes | Genetics. Published online June 23, 2022. doi: 0.1093/g3journal/jkac155

Lapehn S, Paquette AG. The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis. Curr Environ Health Rep. Published online April 29, 2022. doi:10.1007/s40572-022-00354-8

Kruger L, Yue G, Mettu V, Paquette AG, Sathyanarayana S, Prasad B, Differential Proteomics Analysis of JEG-3 and JAR Placental Cell Models and the Effect of Androgen Treatment. J. Steroid Biochem. Mol. Biol. Published online June 8, 2022. doi:10.1016/j.jsbmb.2022.106138

Enquobahrie DA, MacDonald J, Hussey M, Bammler T, Loftus C, Paquette AG, Byington N, Marsit CJ, Szpiro A, Kaufman JD, LeWinn KZ, Bush NR, Tylavsky F, Karr CJ, Sathyanarayana S. Prenatal Exposure to Particulate Matter and Placental Gene Expression. Environmental Research, Published online May 25, 2022. doi: 10.1016/j.envint.2022.107310

2021

Han L, Shi Y, Paquette A, Wang L, Bammler TK, Mao Q. Key hepatic metabolic pathways are altered in germ-free mice during pregnancy. PLoS One. 2021 March 12;16(3): e0248351. doi: 10.1371/journal.pone.0248351. PMID: 33711049

Paquette AG, MacDonald J, Lapehn S, Bammler T, Kruger L, Day DB, Price ND, Loftus C, Kannan K, Marsit CM, Mason WA, Bush NR, LeWinn KZ, Enquobahrie DA, Prasad B, Karr C, Sathyanarayana S. A Comprehensive Assessment of Associations between Prenatal Phthalate Exposure and the Placental Transcriptomic Landscape. Environ Health Perspect. 2021 Sep;129(9):97003. doi: 10.1289/EHP8973. PMID: 34478338.

2020

Paquette AG, Hood L, Price ND, Sadovsky Y. Deep Phenotyping During Pregnancy for Delivery of Predictive and Preventive Medicine. Sci Transl Med. 2020 Jan 22;12(527):eaay1059. doi: 10.1126/scitranslmed.aay1059. PMID: 31969484.

Jelliffe-Pawlowski L, Oltman SP, Rand L, Scott KA, Kuppermann M, Baer R, Bell A, Bandoli G, Costello J, Diamond-Smith N, Epel E, Jackson R, Jiang F, Karasek DA, Lindan C, O’Leary A, Olgin J, Pantell M, Paquette A, Parikh N, Piao X, Prather A, Rutherford G, Ryckman KK, Steurer-Muller M, Stookey J,Srinivasa G,Wright H, McCulloch CE, Piening B. Rogers EE, Chambers C. Examining the Impact of the 2019 Novel Coronavirus and Pandemic-Related Hardship on Adverse Pregnancy and Infant Outcomes: Design and Launch of the HOPE COVID-19 Study. Reprod Med. 2020 July;1(2):91-107. doi: 10.3390/reprodmed1020007.