Publications

Featured Publications

Mono-ethylhexyl phthalate induces overall and sex-specific transcriptomic changes in placental cells 

Lapehn S, Scott Houghtaling S, Ahuna K, Kadam L, MacDonald J, Bammler T, LeWinn K, Karr C, Myatt L, Sathyanarayana S, Paquette AG. Archives of Toxicology, Published 1/25/2023. 

Main Findings

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Paquette AG, Lapehn S, Freije S, MacDonald J, Bammler T, Day D, Loftus C, Kurunthachalam K, W. Alex Mason, PhD; Nicole R. Bush, PhD; Kaja Z LeWinn, ScD; Daniel A. Enquobahrie, MD, PhD, MPH; Carmen Marsit PhD; Catherine J Karr, MD, PhD, MS; Sheela Sathyanarayana, MD, MPH. s. Environment International. Published 1/18/2023. 

Main Findings

All Publications

Note:  Publications here are only include articles published after 2020 and may not be updated. Please check Dr. Paquettes google scholar page or NCBI bibliography for updates.

Preprints


Parenti M, Melough M, Lapehn S, MacDonald JW, Bammler TK, Firsick E, Choi HY, Derefinko KJ, Enquobahrie DA, LeWinn KZ, Bush NR, Zhao Q, Sathyanarayana S, Paquette AG. Associations Between Prenatal Vitamin D and Placental Gene Expression. BioRxiv. DOI: 10.1101/2024.05.10.593571



Lapehn S, Nair S, Firsick E, MacDonald JW, Thoreson C, Litch J, Bush NR, Kadam L, Girard S, Myatt L, Prasad B, Sathyanarayana S, Paquette AG. Transcriptomic comparison of in vitro models of the human placenta. BioRxiv. doi: https://doi.org/10.1101/2024.06.14.598695


Baker B, Sathyanarayana S, Szpiro A, MacDonald J, Paquette AG. RNAseqCovarImpute: a multiple imputation procedure that outperforms complete case and single imputation differential expression analysis. BioRxiv. doi:doi.org/10.1101/2023.05.11.540260


Paquette AG, Ahuna K, Hwang Y, Pearl J, Liao H, Shannon P, Kadam L, Lapehn S, Bucher M, Roper R, Funk C, MacDonald J, Bamler T, Baloni P, Brockway H, Mason A, Bush N, LeWinn K, Karr C, Stamatoyannopoulos J, Muglia L, Jones H, Sadovsky Y, Myatt L, Sathyanarayana S, Price N. A Genome Scale Transcriptional Regulatory Model of the Human Placenta. BioRxiv. Published online September 28, 2022. doi: https://doi.org/10.1101/2022.09.27.509541


2024

Baker B, Freije S, MacDonald J, Bammler T, Benson C, Carroll KN, Enquobahrie DA, Karr CJ, LeWinn K, Zhao Q, Bush N, Sathyanarayana S, Paquette AG. Placental transcriptomic signatures of prenatal and preconceptional maternal stress. Molecular Psychiatry, Published January 11, 2024. DOI: 10.1038/s41380-023-02403-6

 

Baker B, Melough M, Paquette AG, Barrett ES, Day DB, K Kurunthachalam, Nguyen R, Bush NR, LeWinn KZ, Carrol KC, Swan SH, Zhao Q, Sathyanarayana S. Ultra-processed and fast food consumption, exposure to phthalates during pregnancy, and socioeconomic disparities in phthalate exposures. Environment International, Published January 8th, 2024. doi: doi.org/10.1016/j.envint.2024.108427

 

Barrett E, Sullivan A, Workman T, Zhang Yuhong, Loftus C, Szpiro A, Paquette AG, MacDdonald J, Coccia M, Smith R, Bowman M, Smith A, Derefinko K,Nguyen R, Zhao Q, Sathyanarayana S. Karr K, LeWinn K, Bush N, Sex-specific associations between placental corticotropin releasing hormone and problem behaviors in childhood. Psychoneuroendocriniology. Published 2/16/2024. DOI: doi.org/10.1016/j.psyneuen.2024.106994

 

Hwang YM, Roper RT, Piekos SN, Enquobahrie DA, Hebert MF, Paquette AG, Baloni P, Price ND, Hood L, Hadlock J. Timing of selective serotonin reuptake inhibitor use and risk for preterm birth and related adverse events: with a consideration of the COVID-19 pandemic period. The Journal of Maternal-Fetal & Neonatal Medicine. Published 2/11/2024. DOI: 10.1080/14767058.2024.2313364


2023

Elkin A, Campbell KA, Lapehn S, Harris SM, Padmanabhan V, Bakulksi K, Paquette AG.  Placental Single Cell Transcriptomics: Opportunities for Endocrine Disrupting Chemical Toxicology. Molecular and Cellular Endocrinology. Published September 9, 2023. doi: doi.org/10.1016/j.mce.2023.112066

 

Hussey M, Enquobahrie D, Loftus CR, MacDonald JR, Bammler TK, Paquette AG, , Marsit C, Szpiro A, Kaufman J, LeWinn KZ, , Tylavsk F, Bush NR, Zhao Q, Karr C, Sathyanarayana S. Associations of prenatal exposure to NO2 and near roadway residence with placental gene expression. Placenta, Published July 2023. doi:doi.org/10.1016/j.placenta.2023.05.004

 

Laphen S, Gustafson J, Timms A, Cunningham M, Paquette AG. Transcriptomic signatures of single-suture craniosynostosis. International Journal of Molecular Sciences. Published March 10, 2023. doi: doi.org/10.3390/ijms24065353


Correia-Branco A, Mei A, Pillai S, Jayaraman N, Sharma R, Paquette AG, Neradugomma NK,  Benson C, Chavkin N, Mao Q, Wallingford MC. SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis. Vascular Biology. Published April 19, 2023. DOI: doi.org/10.1530/VB-22-0018

 

Lapehn S, Scott Houghtaling S, Ahuna K, Kadam L, MacDonald J, Bammler T, LeWinn K, Karr C, Myatt L, Sathyanarayana S, Paquette AG. Mono-ethylhexyl phthalate induces overall and sex-specific transcriptomic changes in placental cells. Archives of Toxicology, Published 1/25/2023. doi: doi.org/10.1007/s00204-023-03444-0


Paquette AG, Lapehn S, Freije S, MacDonald J, Bammler T, Day D, Loftus C, Kurunthachalam K, W. Alex Mason, PhD; Nicole R. Bush, PhD; Kaja Z LeWinn, ScD; Daniel A. Enquobahrie, MD, PhD, MPH; Carmen Marsit PhD; Catherine J Karr, MD, PhD, MS; Sheela Sathyanarayana, MD, MPH.  Placental Transcriptomic Signatures of Prenatal Exposure to Polycyclic Aromatic Hydrocarbons. Environment International. Published 1/18/2023. doi: 10.1016/j.envint.2023.107763


2022

Kruger L, Yue G, Paquette AG, Sathyanarayana S, Enquobahrie DA, Bammler T, MacDonald J, Zhao Q, Prasad B. An optimized proteomics-based approach to estimate blood contamination and cellular heterogeneity of frozen placental tissue. Placenta. Published 12/23/2022. doi https://doi.org/10.1016/j.placenta.2022.12.007


LeWinn K, Karr C, Hazelhurst M, Carroll K, Loftus C, Nguyen R, Barrett E, Swan S, Spziro A, Paquette AG, Moore P, Spalt E, Younglove L, Sullivan A, Colburn T, Byington N, Sims Taylor L, Moe S, Wang S, Cordeiro A, Mattias A, Powell J, Johnson T, Norona-Zhou A, Mason A, Bush N, Sathyanarayana S. Cohort Profile: The Prenatal and Early Childhood Pathways to Health (PATHWAYS) Consortium. BMJ Open, Published 10/1/2022. doi: http://dx.doi.org/10.1136/bmjopen-2022-064288

 

Paquette AG, MacDonald J, Bammler T, Day DB, Loftus C, Buth E, Mason WA, Bush NR, LeWinn KZ, Marsit CJ, Litch J, Gravett, M, Enquobahrie DA, Sathyanarayana S. Transcriptomic Signatures of Spontaneous Preterm Birth. American Journal of Obstetrics and Gynecology. Published online July 19, 2022.doi: doi.org/10.1016/j.ajog.2022.07.015

 

Hsieh L*, Tu L*, Paquette AG*, Sheng Q, Zhao S, Bittel D, O'Brien J, Vickers K, Pastuzsko P, Nigam V. microRNA Expression Levels Change in Neonatal Patients During and After Exposure to Cardiopulmonary Bypass. Journal Of the American Heart Association, Published 9/6/2022. doi: https://doi.org/10.1161/JAHA.122.025864


Jamet S, Ha S, Ho O, Houghtaling S, Timms A ,Yu K, Paquette AG, Maga M, Greene N, Beier DR. The Arginine Methyltransferase Carm1 is Necessary for Heart Development. G3: Genes | Genomes | Genetics. Published online June 23, 2022. doi: 0.1093/g3journal/jkac155


Lapehn S, Paquette AG. The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis. Curr Environ Health Rep. Published online April 29, 2022. doi:10.1007/s40572-022-00354-8

 

Kruger L, Yue G, Mettu V, Paquette AG, Sathyanarayana S, Prasad B, Differential Proteomics Analysis of JEG-3 and JAR Placental Cell Models and the Effect of Androgen Treatment. J. Steroid Biochem. Mol. Biol. Published online June 8, 2022. doi:10.1016/j.jsbmb.2022.106138

 

Enquobahrie DA, MacDonald J, Hussey M, Bammler T, Loftus C, Paquette AG, Byington N, Marsit CJ, Szpiro A, Kaufman JD, LeWinn KZ, Bush NR, Tylavsky F, Karr CJ, Sathyanarayana S. Prenatal Exposure to Particulate Matter and Placental Gene Expression. Environmental Research, Published online May 25, 2022. doi: 10.1016/j.envint.2022.107310


2021

Han L, Shi Y, Paquette A, Wang L, Bammler TK, Mao Q. Key hepatic metabolic pathways are altered in germ-free mice during pregnancy. PLoS One. 2021 March 12;16(3): e0248351. doi: 10.1371/journal.pone.0248351. PMID: 33711049

 

Paquette AG, MacDonald J, Lapehn S, Bammler T, Kruger L, Day DB, Price ND, Loftus C, Kannan K, Marsit CM, Mason WA, Bush NR, LeWinn KZ, Enquobahrie DA, Prasad B, Karr C, Sathyanarayana S. A Comprehensive Assessment of Associations between Prenatal Phthalate Exposure and the Placental Transcriptomic Landscape. Environ Health Perspect. 2021 Sep;129(9):97003. doi: 10.1289/EHP8973. PMID: 34478338.


2020

Paquette AG, Hood L, Price ND, Sadovsky Y. Deep Phenotyping During Pregnancy for Delivery of Predictive and Preventive Medicine. Sci Transl Med. 2020 Jan 22;12(527):eaay1059. doi: 10.1126/scitranslmed.aay1059. PMID: 31969484.

 

Jelliffe-Pawlowski L, Oltman SP, Rand L, Scott KA, Kuppermann M, Baer R, Bell A, Bandoli G, Costello J, Diamond-Smith N, Epel E, Jackson R, Jiang F, Karasek  DA, Lindan C, O’Leary A, Olgin J, Pantell M, Paquette A, Parikh N, Piao X, Prather A, Rutherford G, Ryckman KK, Steurer-Muller M, Stookey J,Srinivasa G,Wright H, McCulloch CE, Piening B. Rogers EE, Chambers C. Examining the Impact of the 2019 Novel Coronavirus and Pandemic-Related Hardship on Adverse Pregnancy and Infant Outcomes: Design and Launch of the HOPE COVID-19 Study. Reprod Med. 2020 July;1(2):91-107. doi: 10.3390/reprodmed1020007.