Publications
Featured Publications
Mono-ethylhexyl phthalate induces overall and sex-specific transcriptomic changes in placental cells
Lapehn S, Scott Houghtaling S, Ahuna K, Kadam L, MacDonald J, Bammler T, LeWinn K, Karr C, Myatt L, Sathyanarayana S, Paquette AG. Archives of Toxicology, Published 1/25/2023.
Main Findings
The phthalate metabolite MEHP differentially affects placental gene expression based on concentration, fetal sex, and trophoblast cell type
Four Ligand-inducible TFs (PPARG, PPARD, ESR1, AR) were enriched as regulators of genes whose expression was altered after MEHP treatment
A higher number of transcriptomic changes were noted in male primary placental cells, which is concurrent with our work in banked placental tissue samples.
Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons
Paquette AG, Lapehn S, Freije S, MacDonald J, Bammler T, Day D, Loftus C, Kurunthachalam K, W. Alex Mason, PhD; Nicole R. Bush, PhD; Kaja Z LeWinn, ScD; Daniel A. Enquobahrie, MD, PhD, MPH; Carmen Marsit PhD; Catherine J Karr, MD, PhD, MS; Sheela Sathyanarayana, MD, MPH. s. Environment International. Published 1/18/2023.
Main Findings
We identified changes to the placental transcriptome associated with 6 PH Metabolites including multiple associations with TRIP13 and SGF29
Increased expression of genes within pathways involving vitamin digestion and absorption, insulin secretion, and the lysosome-related to 4 OH-PAH metabolites
Evidence that Sex may modify relationships between OH-PAH metabolites and placental gene expression
All Publications
Note: Publications here are only include articles published after 2020 and may not be updated. Please check Dr. Paquettes google scholar page or NCBI bibliography for updates.
Preprints
Parenti M, Melough M, Lapehn S, MacDonald JW, Bammler TK, Firsick E, Choi HY, Derefinko KJ, Enquobahrie DA, LeWinn KZ, Bush NR, Zhao Q, Sathyanarayana S, Paquette AG. Associations Between Prenatal Vitamin D and Placental Gene Expression. BioRxiv. DOI: 10.1101/2024.05.10.593571
Lapehn S, Nair S, Firsick E, MacDonald JW, Thoreson C, Litch J, Bush NR, Kadam L, Girard S, Myatt L, Prasad B, Sathyanarayana S, Paquette AG. Transcriptomic comparison of in vitro models of the human placenta. BioRxiv. doi: https://doi.org/10.1101/2024.06.14.598695
Baker B, Sathyanarayana S, Szpiro A, MacDonald J, Paquette AG. RNAseqCovarImpute: a multiple imputation procedure that outperforms complete case and single imputation differential expression analysis. BioRxiv. doi:doi.org/10.1101/2023.05.11.540260
2024
Paquette AG, Ahuna K, Hwang Y, Pearl J, Liao H, Shannon P, Kadam L, Lapehn S, Bucher M, Roper R, Funk C, MacDonald J, Bamler T, Baloni P, Brockway H, Mason A, Bush N, LeWinn K, Karr C, Stamatoyannopoulos J, Muglia L, Jones H, Sadovsky Y, Myatt L, Sathyanarayana S, Price N. A Genome Scale Transcriptional Regulatory Model of the Human Placenta. Science Advances Published online June 28, 2024. DOI: 10.1126/sciadv.adf3411
Baker B, Freije S, MacDonald J, Bammler T, Benson C, Carroll KN, Enquobahrie DA, Karr CJ, LeWinn K, Zhao Q, Bush N, Sathyanarayana S, Paquette AG. Placental transcriptomic signatures of prenatal and preconceptional maternal stress. Molecular Psychiatry, Published January 11, 2024. DOI: 10.1038/s41380-023-02403-6
Baker B, Melough M, Paquette AG, Barrett ES, Day DB, K Kurunthachalam, Nguyen R, Bush NR, LeWinn KZ, Carrol KC, Swan SH, Zhao Q, Sathyanarayana S. Ultra-processed and fast food consumption, exposure to phthalates during pregnancy, and socioeconomic disparities in phthalate exposures. Environment International, Published January 8th, 2024. doi: doi.org/10.1016/j.envint.2024.108427
Barrett E, Sullivan A, Workman T, Zhang Yuhong, Loftus C, Szpiro A, Paquette AG, MacDdonald J, Coccia M, Smith R, Bowman M, Smith A, Derefinko K,Nguyen R, Zhao Q, Sathyanarayana S. Karr K, LeWinn K, Bush N, Sex-specific associations between placental corticotropin releasing hormone and problem behaviors in childhood. Psychoneuroendocriniology. Published 2/16/2024. DOI: doi.org/10.1016/j.psyneuen.2024.106994
Hwang YM, Roper RT, Piekos SN, Enquobahrie DA, Hebert MF, Paquette AG, Baloni P, Price ND, Hood L, Hadlock J. Timing of selective serotonin reuptake inhibitor use and risk for preterm birth and related adverse events: with a consideration of the COVID-19 pandemic period. The Journal of Maternal-Fetal & Neonatal Medicine. Published 2/11/2024. DOI: 10.1080/14767058.2024.2313364
2023
Elkin A, Campbell KA, Lapehn S, Harris SM, Padmanabhan V, Bakulksi K, Paquette AG. Placental Single Cell Transcriptomics: Opportunities for Endocrine Disrupting Chemical Toxicology. Molecular and Cellular Endocrinology. Published September 9, 2023. doi: doi.org/10.1016/j.mce.2023.112066
Hussey M, Enquobahrie D, Loftus CR, MacDonald JR, Bammler TK, Paquette AG, , Marsit C, Szpiro A, Kaufman J, LeWinn KZ, , Tylavsk F, Bush NR, Zhao Q, Karr C, Sathyanarayana S. Associations of prenatal exposure to NO2 and near roadway residence with placental gene expression. Placenta, Published July 2023. doi:doi.org/10.1016/j.placenta.2023.05.004
Laphen S, Gustafson J, Timms A, Cunningham M, Paquette AG. Transcriptomic signatures of single-suture craniosynostosis. International Journal of Molecular Sciences. Published March 10, 2023. doi: doi.org/10.3390/ijms24065353
Correia-Branco A, Mei A, Pillai S, Jayaraman N, Sharma R, Paquette AG, Neradugomma NK, Benson C, Chavkin N, Mao Q, Wallingford MC. SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis. Vascular Biology. Published April 19, 2023. DOI: doi.org/10.1530/VB-22-0018
Lapehn S, Scott Houghtaling S, Ahuna K, Kadam L, MacDonald J, Bammler T, LeWinn K, Karr C, Myatt L, Sathyanarayana S, Paquette AG. Mono-ethylhexyl phthalate induces overall and sex-specific transcriptomic changes in placental cells. Archives of Toxicology, Published 1/25/2023. doi: doi.org/10.1007/s00204-023-03444-0
Paquette AG, Lapehn S, Freije S, MacDonald J, Bammler T, Day D, Loftus C, Kurunthachalam K, W. Alex Mason, PhD; Nicole R. Bush, PhD; Kaja Z LeWinn, ScD; Daniel A. Enquobahrie, MD, PhD, MPH; Carmen Marsit PhD; Catherine J Karr, MD, PhD, MS; Sheela Sathyanarayana, MD, MPH. Placental Transcriptomic Signatures of Prenatal Exposure to Polycyclic Aromatic Hydrocarbons. Environment International. Published 1/18/2023. doi: 10.1016/j.envint.2023.107763
2022
Kruger L, Yue G, Paquette AG, Sathyanarayana S, Enquobahrie DA, Bammler T, MacDonald J, Zhao Q, Prasad B. An optimized proteomics-based approach to estimate blood contamination and cellular heterogeneity of frozen placental tissue. Placenta. Published 12/23/2022. doi https://doi.org/10.1016/j.placenta.2022.12.007
LeWinn K, Karr C, Hazelhurst M, Carroll K, Loftus C, Nguyen R, Barrett E, Swan S, Spziro A, Paquette AG, Moore P, Spalt E, Younglove L, Sullivan A, Colburn T, Byington N, Sims Taylor L, Moe S, Wang S, Cordeiro A, Mattias A, Powell J, Johnson T, Norona-Zhou A, Mason A, Bush N, Sathyanarayana S. Cohort Profile: The Prenatal and Early Childhood Pathways to Health (PATHWAYS) Consortium. BMJ Open, Published 10/1/2022. doi: http://dx.doi.org/10.1136/bmjopen-2022-064288
Paquette AG, MacDonald J, Bammler T, Day DB, Loftus C, Buth E, Mason WA, Bush NR, LeWinn KZ, Marsit CJ, Litch J, Gravett, M, Enquobahrie DA, Sathyanarayana S. Transcriptomic Signatures of Spontaneous Preterm Birth. American Journal of Obstetrics and Gynecology. Published online July 19, 2022.doi: doi.org/10.1016/j.ajog.2022.07.015
Hsieh L*, Tu L*, Paquette AG*, Sheng Q, Zhao S, Bittel D, O'Brien J, Vickers K, Pastuzsko P, Nigam V. microRNA Expression Levels Change in Neonatal Patients During and After Exposure to Cardiopulmonary Bypass. Journal Of the American Heart Association, Published 9/6/2022. doi: https://doi.org/10.1161/JAHA.122.025864
Jamet S, Ha S, Ho O, Houghtaling S, Timms A ,Yu K, Paquette AG, Maga M, Greene N, Beier DR. The Arginine Methyltransferase Carm1 is Necessary for Heart Development. G3: Genes | Genomes | Genetics. Published online June 23, 2022. doi: 0.1093/g3journal/jkac155
Lapehn S, Paquette AG. The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis. Curr Environ Health Rep. Published online April 29, 2022. doi:10.1007/s40572-022-00354-8
Kruger L, Yue G, Mettu V, Paquette AG, Sathyanarayana S, Prasad B, Differential Proteomics Analysis of JEG-3 and JAR Placental Cell Models and the Effect of Androgen Treatment. J. Steroid Biochem. Mol. Biol. Published online June 8, 2022. doi:10.1016/j.jsbmb.2022.106138
Enquobahrie DA, MacDonald J, Hussey M, Bammler T, Loftus C, Paquette AG, Byington N, Marsit CJ, Szpiro A, Kaufman JD, LeWinn KZ, Bush NR, Tylavsky F, Karr CJ, Sathyanarayana S. Prenatal Exposure to Particulate Matter and Placental Gene Expression. Environmental Research, Published online May 25, 2022. doi: 10.1016/j.envint.2022.107310
2021
Han L, Shi Y, Paquette A, Wang L, Bammler TK, Mao Q. Key hepatic metabolic pathways are altered in germ-free mice during pregnancy. PLoS One. 2021 March 12;16(3): e0248351. doi: 10.1371/journal.pone.0248351. PMID: 33711049
Paquette AG, MacDonald J, Lapehn S, Bammler T, Kruger L, Day DB, Price ND, Loftus C, Kannan K, Marsit CM, Mason WA, Bush NR, LeWinn KZ, Enquobahrie DA, Prasad B, Karr C, Sathyanarayana S. A Comprehensive Assessment of Associations between Prenatal Phthalate Exposure and the Placental Transcriptomic Landscape. Environ Health Perspect. 2021 Sep;129(9):97003. doi: 10.1289/EHP8973. PMID: 34478338.
2020
Paquette AG, Hood L, Price ND, Sadovsky Y. Deep Phenotyping During Pregnancy for Delivery of Predictive and Preventive Medicine. Sci Transl Med. 2020 Jan 22;12(527):eaay1059. doi: 10.1126/scitranslmed.aay1059. PMID: 31969484.
Jelliffe-Pawlowski L, Oltman SP, Rand L, Scott KA, Kuppermann M, Baer R, Bell A, Bandoli G, Costello J, Diamond-Smith N, Epel E, Jackson R, Jiang F, Karasek DA, Lindan C, O’Leary A, Olgin J, Pantell M, Paquette A, Parikh N, Piao X, Prather A, Rutherford G, Ryckman KK, Steurer-Muller M, Stookey J,Srinivasa G,Wright H, McCulloch CE, Piening B. Rogers EE, Chambers C. Examining the Impact of the 2019 Novel Coronavirus and Pandemic-Related Hardship on Adverse Pregnancy and Infant Outcomes: Design and Launch of the HOPE COVID-19 Study. Reprod Med. 2020 July;1(2):91-107. doi: 10.3390/reprodmed1020007.